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Chelation therapy in chronic iron overload a CIBA Medical Horizons symposium, New York City, May 19, 1977

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Published by Symposia Specialists in Miami, Fla .
Written in English


  • Thalassemia -- Chemotherapy -- Congresses.,
  • Hemosiderosis -- Chemotherapy -- Congresses.,
  • Deferoxamine -- Congresses.,
  • Blood -- Transfusion -- Complications -- Congresses.,
  • Chelation therapy -- Congresses.

Book details:

Edition Notes

Includes bibliographical references.

Other titlesChronic iron overload.
Statementcosponsored by Cooley"s Anemia Blood and Research Foundation for Children ; edited by Edward C. Zaino, Richard H. Roberts.
ContributionsZaino, Edward C., 1918-, Roberts, Richard H., Ciba Medical Horizons., Cooley"s Anemia Blood and Research Foundation for Children.
LC ClassificationsRC641.7.T5 C46
The Physical Object
Paginationx, 144 p. :
Number of Pages144
ID Numbers
Open LibraryOL4571797M
ISBN 100883721015
LC Control Number77092189

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  Deferoxamine has long term data to support its use as a chelation agent in chronic iron overload in both adult and children. Following the introduction of deferoxamine survival rates for thalassemia patients increased substantially within a decadeMorbidity from organ system toxicity as decreased significantly as Size: 68KB. The financial burden of caring chelation therapy in iron overload is an emerging medical problem in developing countries. The objective of this study was to compare the cost of different mode of. Background: Iron chelation therapy (ICT) is important for chronic conditions where blood transfusions are an essential therapy (eg transfusion-dependent thalassemia [TDT], sickle-cell disease and myelodysplastic syndromes), to avoid serious long-term clinical consequences of iron overload. There are currently three iron chelators licensed to treat iron overload: deferoxamine Cited by: 3. Clinical consequences of iron overload from chronic red blood cell transfusions, its diagnosis, and its management by chelation therapy Aryeh Shander From the Department of Anesthesiology, Critical Care Medicine, and Hyperbaric Medicine, Englewood Hospital and Medical Center, Englewood, New Jersey; and LifeSouth Community Blood Centers.

Iron Overload and Iron Chelation: The Inside Story Jerry L. Spivak, MD • Iron therapy cannot correct the anemia of chronic disease in the absence of tissue iron deficiency • Pharmacologic concentrations of EPO can correct the anemia of chronic disease but not iron deficiency anemia.   In myelofibrosis, the clinical impact of iron overload and the potential for meaningful intervention with iron chelation therapy has not been adequately explored, particularly in the era of JAK2 inhibitor therapy. Research agenda • Iron overload in myelofibrosis is poorly studied and warrants further study to fully characterize its clinical. Iron chelation therapy removes the iron gained from blood transfusion or increased gastrointestinal iron absorption. Iron overload causes serious complications in the endocrine system. Despite not fully conclusive, these and more recent studies, including the TELESTO trial, unravel an overall adverse action of iron overload and therapeutic benefit of chelation, ranging from improved hematological outcome, reduced transfusion dependence and superior survival of iron-loaded MDS patients.

The goals of iron chelation therapy are to remove the amount of iron administered in transfusions and to prevent the accumulation of iron reaching harmful levels. Chelation therapy helps eliminate iron from the body, primarily through the feces. Some studies show that patients experiencing iron overload who receive chelation therapy have a significantly greater life expectancy than those who do .   The most common iron chelator used in the United States is deferasirox. It is effective at removing iron from the liver and heart, the two organs most likely to have iron overload. Deferasirox comes in two formulations: a dispersible tablet (dissolved in liquid) called Exjade and a tablet that can be swallowed called Jadenu. Iron chelation therapy is used when you have a condition called iron overload. Iron overload means you have too much iron in your body. This can be a problem for people who get lots of red blood cell transfusions. Since red blood cells contain iron, each time you get a red blood cell transfusion you are putting more iron in your body. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron .